Who portrays Karen Wheeler? What actress takes on the role of Karen Wheeler in the show? Who is the performer behind Karen Wheeler? Karen is depicted by which actress? Which actor acts as the character of Karen the mother on the series? Whom is the talent personifying Karen Wheeler's character to life? What performer takes on the role of Karen Mrs. Wheeler in the series? Whoever acts Karen Wheeler? Who is the talented individual portraying Karen the mother on the show? What actress embodies the character of Karen Wheeler to the screen?